Several research studies now show that people who suffer acne are under higher levels of inflammation and have inadequate amounts of the essential antioxidant enzymes that are necessary for our biological systems to detoxify frre radicals, prevent oxidation and deal with oxidative stress.
Victoria O'Driscoll dermatologist at Andes Natural explains: "Oxidation is a chemical reaction that moves electrons or hydrogen from a substance to an oxidizing agent. Oxidation reactions can produce toxic free radicals. In turn, these radicals can begin a domino effect with the production of peroxides. When a chain reaction occurs in a cell, it can cause damage to all components including proteins, lipids, and DNA, and cause the death of the cell. Antioxidants cancel these domino effects by getting rid of free radical intermediates, and hinder other oxidation reactions. They do this by being oxidized themselves, so anti-oxidants are frequently reducing agents".
Oxidative stress is the imbalance between the systemic manifestation of reactive molecules consisting of oxygen ions and peroxides (ROS or Reactive Oxygen Species) and the biological capability of our system to readily cleanse and minimize (redox) the ROS formed as a natural result of the typical metabolic process of oxygen, and repair the resulting damage.
Superoxide dismutase and glutathione peroxide antioxidant enzymes in the skin of acne patients end up being exhausted at a very quick rate.
Studies have found 43 % higher hydrogen peroxide production in acne victims as compared to healthy controls. One research revealed likewise considerable differences in inflammation markers and anti-inflammatory molecules between those with moderate and severe acne. People with severe acne had a lot even more inflammation and less antioxidant enzymes than those with moderate acne.
The inflammation comes from injuries brought upon the cells lining the walls of the sebum ducts by hard solidified sebum and the subsequent reaction of the immune cells that live amongst our tissues.
They fire the inflammatory cascade even before living cells are injured, as soon as they identify that sebum has started to change its composition to a pasty thickened sebum instead of staying liquid. This is caused by the exhaustion of linoleic acid in the sebaceous glands when too much sebum is being produced.
Inflammation can likewise originate from other sources, such as gut issues, consuming foods you are sensitive, stress and rest deprival.
The inflammatory cascade produces volumes of toxic free radicals in its effort to destroy the sebum that has ended up being solidified. Anti-oxidants similarly end up diminished.
Without adequate anti-oxidants sebum gets oxidized. Sebum composition in acne patients has more squalene (a fatty acid), perhaps because squalene is rather resistant to oxidation (i.e. it can take much more abuse than many other fatty acids).
When squalene gets oxidized it becomes squalene peroxide. Trouble is squalene peroxide in the skin starts an inflammatory cascade that continues to lessen the supply of anti-oxidants to the skin.
Solidified and oxidized sebum combines with dead cells been shed of as they die inside the sebum ducts. The mix develops a paste that blocks the pores. Inside blocked pores there is no oxygen and then acne bacteria that generally in small numbers in the sebaceous glands deep inside the hair follicles start multiplying at a high rate and colonizing the whole sebum duct not just the sebaceous gland.
In the upper part of the hair follicle or sebum duct acne germs feed upon sebum and their metabolic waste chemicals corrode (injure) the cells lining the walls of the sebum ducts, which yields more inflammatory reactions. A perpetual inflammatory cascade turns a reasonably gently obstructed pore into an upset, red zit.
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When a chain reaction takes place in a cell, it can cause damage to all parts including proteins, lipids, and DNA, and lead to the death of the cell. Anti-oxidants end these chain reactions by eliminating free radical intermediates, and inhibit other oxidation reactions. They do this by being oxidized themselves, so antioxidants are typically reducing agents".
This initial inflammation helps the P. Acnes bacteria to colonize the skin pore because hardened and oxidized sebum combines with dead cells been shed of as they pass away inside the sebum ducts. Inside blocked pores there is no oxygen and then acne bacteria that typically live in the sebaceous glands deep inside the hair roots begin increasing at a high rate and colonizing the whole sebum duct not just the sebaceous gland.